![]() ![]() Failure to do this risks misleading conclusions being drawn, with consequent effects on clinical practice. NEJM Evidence, a new monthly digital journal from NEJM Group, presents innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. Authors should clearly describe the methods used and provide clear descriptions of and justifications for their design and primary analysis. CONCLUSIONS: Reporting and conduct of non-inferiority trials is inconsistent and does not follow the recommendations in available statistical guidelines, which are not wholly consistent themselves. Missing data were rarely considered with (99 59%) not declaring whether imputation techniques were used. This review focuses on aspiration involving the lung parenchyma. with the highest impact factor in the world: The BMJ and the New England Journal of Medicine. ![]() There was lack of clarity or inconsistency between the type I error rate and corresponding CIs for 73 (43%) articles. Aspiration syndromes may involve the airways or pulmonary parenchyma, resulting in a variety of clinical presentations. Date: MaSource: Baylor Scott & White Health. While most chose two different analyses (91 54%) the most common being intention-to-treat (ITT) or modified ITT and per-protocol, a large number of articles only chose to conduct and report one analysis (65 39%), most commonly the ITT analysis. The non-inferiority margin was reported for 98% (164), but less than half reported any justification for the margin (77 46%). Most trials concluded non-inferiority (132 79%). Of these enrollees, 110 children (mean ±SD age, 18☒ months) who did not have a response to the nutritional. Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of. RESULTS: A total of 168 trial publications were included. From July 2016 through July 2018, we enrolled 525 children in our study. ![]() METHODS: We searched for non-inferiority trials and assessed the following: choice of non-inferiority margin and justification of margin power and significance level for sample size patient population used and how this was defined any missing data methods used and assumptions declared and any sensitivity analyses used. DESIGN: Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medicine, Annals of Internal Medicine, BMJ, JAMA, Lancet and New England Journal of Medicine). OBJECTIVE: To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. ![]()
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